Contents FOREWORD .............................................................................................................. 3 EXECUTIVE SUMMARY ........................................................................................... 5 INTRODUCTION ........................................................................................................ 7 SCOPE, AUDIENCE, AND PURPOSE ................................................................... 10 INFLUENZA RESPONSE ACTIVITIES ................................................................... 11 PLANNING TOOLS FOR PREPARATION AND RESPONSE ............................... 12 THE 2017 UPDATE TO THE HHS PANDEMIC INFLUENZA PLAN ..................... 13 Domain 1 – Surveillance, Epidemiology, and Laboratory Activities .................. 14 Domain 2 – Community Mitigation Measures .................................................... 18 Domain 3 – Medical Countermeasures: Diagnostic Devices, Vaccines, Therapeutics, and Respiratory Devices ............................................................. 21 Domain 4 – Health Care System Preparedness and Response Activities ....... 27 Domain 5 – Communications and Public Outreach ........................................... 30 Domain 6 – Scientific Infrastructure and Preparedness .................................... 32 Domain 7 – Domestic and International Response Policy, Incident Management, and Global Partnerships and Capacity Building ......................... 35 CONCLUSIONS ....................................................................................................... 40 APPENDIX A ............................................................................................................ 41 PLANNING SCENARIOS......................................................................................... 41 Planning Assumptions ........................................................................................ 42 Table A.1. Estimated Illness, Types of Medical Care, and Deaths from a Moderate to Very Severe Influenza Pandemic ................................................................................................ 44 APPENDIX B ............................................................................................................ 45 PLANNING TOOLS .................................................................................................. 45 Pandemic Intervals Framework .......................................................................... 46 Figure B.1. Preparedness and response framework for novel influenza A virus pandemics: CDC intervals....................................................................................................................... 47 Table B.1. Preparedness and response framework for novel influenza A virus pandemics: World Health Organization phases and CDC intervals, with federal and state/local indicators.............................................................................................................................. 48 Influenza Risk Assessment Tool (IRAT) ............................................................ 50 Pandemic Severity Assessment Framework (PSAF) ........................................ 51